教育背景:

2003.09-2010.02  美國紐約州立大學Albany分校，公共衛生學院環境健康科學系，博士，導師Xinxin Ding教授

1999.09-2003.07  南京大學，生命科學學院生物化學專業，學士，導師沈萍萍教授

工作經曆:

代表性論文:

1. Wang Y, Chen Q, Wu S, Sun Y, Yin R, Ouyang Z, Yin H*, Wei Y*. Amelioration of Ethanol-Induced Oxidative Stress and Alcoholic Liver Disease by RNAi in vivo Targeting Cyp2e1, Acta Pharmaceutica Sinica B, in press（doi.org/10.1016/j.apsb.2023.01.009）

2.Fan X, Chen J, Zhang Y, ...Wei Y*, Xiao Y*. Alpinetin promotes hair regeneration via activating hair follicle stem cells. Chinese Medicine, 2022, 17(1), 63

3.Sun X, Lv W, Wang Y, Zhang X, Ouyang, Yin R*, Wei Y*. Mrgprb2 gene plays a role in the anaphylactoid reactions induced by Houttuynia cordata injection, Journal of Ethnopharmacology, 2022, 289(May)

4.Zhou H, Yang L, Wang C, Li Z, Ouyang Z, Shan M, Gu J*, Wei Y*. CYP2D1 Gene Knockout Reduces the Metabolism and Efficacy of Venlafaxine in Rats. Drug Metab Dispos. 2019 Dec;47(12):1425-1432

5.Ye H, Sui D, Liu W, Yuan Y, Ouyang Z, Wei Y*. Effects of CYP2C11 Gene Knockout on the Pharmacokinetics and Pharmacodynamics of Warfarin in Rats. Xenobiotica. 2019 Dec; 49(12):1478-1484.

6.Liu W, Sui D, Ye H, Ouyang Z, Wei Y*. CYP2C11 played a significant role in down-regulating rat blood pressure under the challenge of a high-salt diet. PeerJ. 2019 Apr; 7: e6807.

7.Wei Y, Wang L, Wang D, Wang D, Wen C, Han B, Ouyang Z*. Characterization and anti-tumor activity of a polysaccharide isolated from Dendrobium officinale grown in the Huoshan County. Chin Med. 2018 Sep; 13: 47.

8.Wei Y*, Wang D, Chen M, Ouyang Z, Wang S, Gu J*. Extrahepatic cytochrome P450s play an insignificant role in triptolide-induced toxicity. Chin Med. 2018 Apr; 13: 23.

9.Wei Y*, Yang L, Zhang X, Sui D, Wang C, Wang K, Shan M, Guo D, Wang H. Generation and Characterization of a CYP2C11-null Rat Model by using the CRISPR/Cas9 method. Drug Metab Dispos. 2018 May; 46(5):525-531.

10.Wei Y*, Sui D J, Xu H M, et al. Atractylodes lancea rhizome water extract reduces triptolide-induced toxicity and enhances anti-inflammatory effects. Chin J Nat Med. 2017 Dec; 15(12):905-911.

11.Wang D, Wang K, Sui D, Ouyang Z, Wei Y*. Effects of tetrahydroberberine and tetrahydropalmatine on hepatic cytochrome P450 expression and their toxicity in mice. Chem Biol Interact. 2017 Apr; 268: 47-52.

12.Wei Y^#, Li L^#, Zhou X, Zhang QY, Dunbar A, Liu F, Kluetzman K, Yang W, Ding X*.Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model. Drug Metab Dispos. 2013 Jan;41(1):132-40.

13.Wei Y, Wu H, Li L, Liu Z, Zhou X, Weng Y, D'Agostino J, Ling G, Zhang L, Kluetzman K, Yao Y, Zhang QY, and Ding X*. Generation and characterization of a CYP 2A 13/2B6/ 2F 1 -transgenic mouse model. Drug Metab Dispos. 2012 Jun;40(6):1144-50.

14.Li L^#, Wei Y ^#, Van Winkle L, Zhang QY, Zhou X, Hu J, Xie F, Kluetzman K, Ding X*. Generation and characterization of a Cyp 2f 2-null mouse and studies on the role of CYP 2F 2 in naphthalene-induced toxicity in the lung and nasal olfactory mucosa. J Pharmacol Exp Ther.2011 Oct;339(1):62-71.

15.Wei Y, Zhou X, Fang C, Li L, Kluetzman K, Yang W, Zhang QY, Ding X*.Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues. J Pharmacol Exp Ther.2010 Jul;334(1):69-77.

基金項目:

1. 國家重點研發計劃（子課題）, 2020YFE0205100, 中國-奧地利中藥防治重大感染性疾病 “一帶一路”聯合實驗室建設與聯合研究， 2021-2023， 35萬元，主持

2. 中央本級重大增減支項目，名貴中藥資源可持續利用能力建設項目：道地藥材蘇薄荷化學型形成的分子機制研究（項目代碼：2060302），2020-2022，27萬元，主持

3. 國家自然科學基金 (面上項目): 基于TALEN技術的細胞色素P450基因敲除大鼠模型的構建與應用（項目代碼：81373480），2014-2017，65萬元，主持

4. 國家自然科學基金（青年項目）：基于XH-CL基因敲除小鼠模型的雷公藤内酯醇肝外組織代謝與毒理研究（項目代碼：81102522），2012-2014，22萬元，主持

5. 江蘇省自然科學基金：肝外細胞色素P450代謝在雷公藤内酯醇多系統毒性中的作用研究（項目代碼：BK2011473），2012-2014，10萬元，主持  

6. 江蘇省“青藍工程”青年骨幹教師基金項目，2012-2016，主持

學術兼職:

國際藥物代謝學會（ISSX）會員

中華中醫藥學會中藥毒理與安全性評價分會委員

中國中西醫結合學會分子生藥學專業委員會委員

聯系方式:

電子郵件：ywei@ujs.edu.cn