胡磊，博士，教授，碩士研究生導師。

研究方向

動态組合化學為指導的酶抑制劑研發

酶催化生物活性分子不對稱合成

高效表面活性劑研發

醫藥中間體合成研發

招收藥物化學研究方向的學術型研究生以及生物與醫藥（前制藥工程）專業學位研究生，歡迎具有制藥工程、藥學、化學、生物等相關學習背景的同學報考。

聯系方式

辦公室：藥學樓2413室

實驗室：藥學樓2404室

微信：36396672

Email：leihu@ujs.edu.cn

教育背景：

2010.10至2014.10 瑞典皇家工學院 KTH-Royal Institute of Technology 有機化學博士

2007.09至2010.06 暨南大學藥學院 藥物化學專業碩士

2003.09至2007.06 湖南師範大學 制藥工程專業學士

工作經曆：

2017.04至今 世界杯正规买球app 教授

2014.12至2016.08 美國俄亥俄州立大學 The Ohio State University化學系 博士後研究員

代表性科研成果：

Wu, Y., Zhao, S., Liu, C., Hu, L.*, Development of Urease Inhibitors by Fragment-Based Dynamic Combinatorial Chemistry. ChemMedChem., 2022, e202200307.

Wu, Y., Zhao, S., Hu, L.*, Identification of Potent α-Amylase Inhibitors via Dynamic Combinatorial Chemistry. Bioorgan. Med. Chem., 2022, 55, 116609. (封面文章)

Zhao, S., Wu, Y., Hu, L.*, Identification and Synthesis of Selective Cholesterol Esterase Inhibitor using Dynamic Combinatorial Chemistry. Bioorg. Chem., 2022. 119. 105520.

Li, Y., Xu. J., Hu, L.*, Synthesis and Comparative Studies on the Surface-active and Biological

Properties of Linear Poly(glycidol) Esters. J. Mol. Liq., 2022. 360. 119538.

Han, M., Xu, J., Hu, L.*, Biocatalytic Enantioselective Construction of 1,3-Oxathiolan-5-ones via Dynamic Covalent Kinetic Resolution of Hemithioketals. Mol. Catal., 2022. 519. 112114.

Zhang, S., Li, Y., Hu, L.*, Physical and Biological Evaluation of Glucose Hydrazones as Biodegradable Emulsifiers. J. Mol. Liq., 2022. 350. 118224.

Zhang, S., Li, Y., Han, M., Wu, Y., Hu, L.*, Comparative Study of Surface-Active and Biological Properties of Lactose-derived Acylhydrazones. J. Mol. Liq., 2021. 322. 114989.

Zhao, S., Xu, J., Zhang, S., Han, M., Wu, Y., Li, Y., Hu, L.*, Multivalent Butyrylcholinesterase Inhibitor Discovered by Exploiting Dynamic Combinatorial Chemistry. Bioorg. Chem., 2021. 108. 104565.

Zhao, S., Zhang, S., Xu, J., Hu, L.*, Synthesis and Comparative Study of Emulsifying and Biological Properties of Triazolated Glucolipids. Tetrahedron, 2020, 76, 131517.

Xu, J.¹, Zhao, S.¹, Zhang, S., Hu, L.*, Development of a Multivalent Acetylcholinesterase Inhibitor via Dynamic Combinatorial Chemistry. Int. J. Biol. Macromol., 2020, 150, 1184.

Xu, J., Zhao, S., Zhang, S., Hu, L.*, Identification and Synthesis of An Efficient Multivalent E. coli Heat Labile Toxin Inhibitor - A Dynamic Combinatorial Chemistry Approach. Bioorgan. Med. Chem., 2020, 28, 115436.

Xu, J., Hu, L.*, Asymmetric One-pot Synthesis of Five- and Six-membered Lactones via Dynamic Covalent Kinetic Resolution: Exploring the Regio- and Stereoselectivities of Lipase. Tetrahedron Lett., 2019, 60, 868.

Hu, L.; Polen, S.; Hardin, A.; Pratumyot, Y.; Hadad, C.; Badjić, J. On the Transfer of Chirality, Thermodynamic Stability, and Folding Characteristics of Stereoisomeric Gated Baskets. Eur. J. Org. Chem., 2015, 31, 6832.

Hu, L.; Zhang, Y.; Ramström, O. Gelation-driven Dynamic Systemic Resolution: in situ Generation and Self-Selection of an Organogelator. Sci. Rep., 2015, 5, 11065.

Hu, L.; Ren, Y., Ramström, O. Chirality Control in Enzyme-Catalyzed Dynamic Kinetic Resolution of 1,3-Oxathiolanes. J. Org. Chem., 2015, 80, 8478.

Schaufelberger, F.; Hu, L.; Ramström, O. trans-Symmetric Dynamic Covalent Systems: Connected Transamination and Transimination Reactions. Chem. Eur. J., 2015, 21, 9776.

Hu, L.; Ramström, O. Silver-Catalyzed Dynamic Systemic Resolution of α-Iminonitriles in a 1,3-Dipolar Cycloaddition Process. Chem. Commun., 2014, 50, 3792.

Hu, L.; Zhang, Y.; Ramström, O. Lipase-Catalyzed Asymmetric Synthesis of Oxathiazin-anones through Dynamic Covalent Kinetic Resolution. Org. Biomol. Chem., 2014, 12, 3572.

Hu, L.; Schaufelberger, F.; Timmer, B. J. J.; Abellán Flos, M.; Ramström, O. Dynamic Constitutional Chemistry. In: Kirk-Othmer Encyclopedia of Chemical Technology., John Wiley & Sons, Inc., 2014. DOI: 10.1002/0471238961.consrams.a01

Hu, L.; Schaufelberger, F.; Zhang, Y.; Ramström, O. Efficient Asymmetric Synthesis of Lamivudine via Enzymatic Dynamic Kinetic Resolution. Chem. Comm. 2013, 49, 10376.

Hu, L; Lan, P; Song, Q; Huang, Z; Sun, P; Zhuo, C; Wang, Y; Xiao, S; Chen, WM. Synthesis and Antibacterial Activity of C-12 Pyrazolinyl Spiro Ketolides. Eur. J. Med. Chem., 2010, 45, 5943.

主持項目：

江蘇省六大人才高峰項目 在研

醫藥中間體的合成工藝開發 企業委托項目 在研

江蘇省自然科學基金青年項目 結題

中國博士後面上基金 結題

江蘇省日常資助博士後項目 結題

江蘇省雙創博士項目 結題

江蘇大學高級人才啟動基金 結題

主講課程

藥物化學

波譜解析（留學生）

健康科學導論（留學生）

天然藥物化學（留學生）