屠言貝，男，博士，世界杯正规买球app資格副教授，碩士生導師，澳門青年學者。2021年畢業于澳門大學中藥質量研究國家重點實驗室，獲生物醫藥專業博士學位，主要從事中藥及其活性成分的藥效靶點發現及天然産物藥物研發等研究工作。目前正式發表SCI檢索論文29篇，其中以第一作者身份在Pharmacological Research、Journal of Agricultural and Food Chemistry、Biochemical Pharmacology、Journal of Ethnopharmacology等期刊發表SCI論文10餘篇。

ResearchGate學術主頁：https://www.researchgate.net/profile/Yanbei_Tu

【聯系方式】

Email：yanbeitu@ujs.edu.cn

地址：世界杯正规买球app 中藥學與藥學系

【教育及工作經曆】

2023.01至今，澳門大學，中藥質量研究國家重點實驗室，澳門青年學者

2021-12至今，江蘇大學，藥學院，資格副教授

2016-08至2021-08，澳門大學，中藥質量研究國家重點實驗室，生物醫藥專業，博士

2013-09至2016-06，四川大學，制藥與生物工程系，生物化工專業，碩士

2009-09至2013-06，四川大學，制藥與生物工程系，生物工程專業，學士

【研究方向】

1.中藥及其活性成分抗關節炎和骨質疏松症的藥理作用及藥效機制

2.化學蛋白質組學技術與中藥活性成分的藥效靶點發現

3.載中藥活性成分的藥物遞送系統設計及評價

【主持科研及人才項目】

1.國家自然科學基金青年科學基金項目，基于Syk激酶靶向調控探讨Dolichosin A治療類風濕關節炎的機制研究（編号82204724），2023-01-01至2025-12-31，在研，主持

2.江蘇大學高級人才科研啟動基金（編号5501290014），2022至2024，在研，主持

3.澳門青年學者項目，2023-01-03至2025-01-02，在研，主持

【代表性論文】

1.Tu, Y., Tan, L., Lu, T., Wang, K., Wang, H., Han, B., ... & He, C*. (2022). Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways. Biochemical Pharmacology, 197, 114912.

2.Tu, Y., Yang, Y., Li, Y., & He, C*. (2021). Naturally occurring coumestans from plants, their biological activities and therapeutic effects on human diseases. Pharmacological Research, 169, 105615.

3.Tu, Y., Wang, K., Jia, X., Tan, L., Han, B., Zhang, Q., ... & He, C*. (2020). Isolation and Identification of antiarthritic Constituents from Glycine tabacina and Network Pharmacology-Based Prediction of Their Protective Mechanisms against Rheumatoid Arthritis. Journal of Agricultural and Food Chemistry, 68, 10664-10677.

4.Tu, Y., Wang, K. , Tan, L., Han, B., Hu, Y., Ding, H.*, & He, C*. (2020). Dolichosin A, a coumestan isolated from Glycine tabacina, inhibits IL-1β-induced inflammation in SW982 human synovial cells and suppresses RANKL-induced osteoclastogenesis: From network pharmacology to experimental pharmacology. Journal of Ethnopharmacology, 258, 112855.

5.¹Tan, L. , ¹Tu, Y. , ¹Wang, K., Han, B., Peng, H., & He, C*. (2020). Exploring protective effect of Glycine tabacina aqueous extract against nephrotic syndrome by network pharmacology and experimental verification. Chinese Medicine, 15, 79. (Co-first author)

6.¹Tu, Y.B., ¹Xiao, T., Gong, G.Y., Bian, Y.Q., & Li, Y.F*. (2020). A new isoflavone with anti-inflammatory effect from the seeds of Millettia pachycarpa. Natural Product Research, 34, 981-987.

7.Tu, Y., Wang, K., Wan, J. B., & He, C*. (2019). Anti-inflammatory effects of Glycine tabacina extract in LPS-stimulated macrophages and collagen-induced arthritis mice. Journal of Functional Foods, 62, 103528.

8.¹Tu, Y., ¹Wang, K., Liang, Y., Jia, X., Wang, L., Wan, J. B., ... & He, C*. (2019). Glycine tabacina ethanol extract ameliorates collagen-induced arthritis in rats via inhibiting pro-inflammatory cytokines and oxidation. Journal of Ethnopharmacology, 237, 20-27.

9.Tu, Y., Wu, C., Kang, Y., Li, Q., Zhu, C., & Li, Y*. (2019). Bioactivity-guided identification of flavonoids with cholinesterase and β-amyloid peptide aggregation inhibitory effects from the seeds of Millettia pachycarpa. Bioorganic & Medicinal Chemistry Letters, 29, 1194-1198.

10.Tu, Y., Huang, J., & Li, Y*. (2018). Anticholinesterase, antioxidant, and beta-amyloid aggregation inhibitory constituents from Cremastra appendiculata. Medicinal Chemistry Research, 27, 857-863.

11.Tu, Y., Zhong, Y., Du, H., Luo, W., Wen, Y., Li, Q., ... & Li, Y*. (2016). Anticholinesterases and antioxidant alkamides from Piper nigrum fruits. Natural Product Research, 30, 1945-1949.

【授權專利】

1.何承偉；屠言貝；王恺；一種化合物、其制備方法及應用以及抗類風濕性關節炎的藥物，2021-7-20，中國，ZL 2020 1 0456036.6.

2.何承偉；屠言貝；王恺；一種化合物、其制備方法及應用以及抗類風濕性關節炎的藥物，2021-5-18，中國，ZL 2020 1 0457352.5.

3.何承偉；屠言貝；王恺；張慶文；一種化合物、其制備方法及應用以及抗類風濕性關節炎的藥物，2020-12-8，中國，ZL 2019 1 0569463.2.

4.李延芳； 屠言貝；厚果崖豆藤中抑制乙酰和丁酰膽堿酯酶的黃酮類化合物及其用途，2019-10-8，中國，ZL 2017 1 0099660.3.