師資隊伍

副教授

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芮蒙傑 副教授

信息來源: 發布日期:2019-06-14

   

主要研究方向

近年來從事新型的多功能生物材料研究,結合多學科交叉研究的優勢,通過結構設計和可控修飾得到模拟生物活性的大分子材料,在靶向藥物輸送、腫瘤治療和多模态生物影像等多個領域進行綜合應用,并證明了這些大分子材料在提高腫瘤治療的特異性和有效性、實現精準治療等方面具有獨特的優勢。在國際學術期刊上發表多篇學術論文,其中包括Molecular PharmaceuticsInternational journal of pharmaceutics等藥劑領域專業期刊。研究成功先後獲得國家自然科學青年基金、江蘇省自然科學青年基金以及面上項目等項目資助。

主要研究方向及興趣包括:

1. 新型仿生納米材料的開發及其在藥物輸送、治療研究和生物成像上的應用

2. 多功能敏感型納米材料在生物成像、腫瘤治療與聯合治療上的應用

受教育及研究工作經曆

2017.05-至今,江蘇大學,藥學院,藥劑學系,副教授

2013.03-2017.04 江蘇大學,藥學院,藥劑學系,講師

2008.09-2012.12,上海交通大學,生命科學技術學院,生物醫學工程,博士,導師:徐宇虹教授

2004.09-2008.06,上海交通大學,生命科學技術學院,生物工程,學士

主要科研項目

1、江蘇省自然科學基金面上項目(BK20181445),201807-202106,主持。

2、國家自然科學基金青年科學基金項目(81402880),201501-201712,主持。

3、江蘇省自然科學基金青年項目(BK20130541),201307-201607,主持。

4、江蘇大學高級人才科研啟動基金(14JDG163),201407-202006,主持。

5、國家自然科學基金青年科學基金項目(81102395),201201-201412,參加。

招生方向:

熱忱歡迎有志從事科研工作的本科生、研究生到我們課題組學習工作。歡迎具有藥學、生物醫學、化學以及材料背景的同學報考。有疑問可郵件聯系

講授課程:

制劑工程學

工業藥劑學

Preparation Equipment and Process Design Workshop(海外教育學院)

Industrial Pharmaceutics(海外教育學院)

Pharmaceutical Molecular Biology(海外教育學院)

  

代表性論文:

1. Chunlai Feng, Haisheng Zhang, Jiaming Chen, Siqi Wang, Yuanrong Xin, Yang Qu, Qi Zhang, Wei Ji, Fumiyoshi Yamashita, and Mengjie Rui*. Ratiometric Co-Encapsulation and Co-Delivery of Doxorubicin and Paclitaxel by Tumor-Targeted Lipodisks for Combination Therapy of Breast Cancer. International journal of pharmaceutics, 560 (2019): 191-204.

2. Chunlai Feng, Xianqin Yuan, Kexin Chu, Haisheng Zhang, Wei Ji, and Mengjie Rui*. Preparation and Optimization of Poly (Lactic Acid) Nanoparticles Loaded with Fisetin to Improve Anti-Cancer Therapy. International journal of biological macromolecules, 125 (2019): 700-10.

3. Hailing Tang, Mengjie Rui, Chuang Yu, Tao Chu, Chao Li, Zhenzhen Zhan, Hao Cao, Hangwen Li, Zhongmin Liu, and Haifa Shen. Nanotechnology in Generation and Biomedical Application of Induced Pluripotent Stem Cells. Nano Life, 8, no. 04 (2018): 1841002.

4. Qi Zhang, Jian Zhang, Song Xue, Mengjie Rui, Bin Gao, Ang Li, Jiashuai Bai, Zhichao Yin, and Ebubedike Mitchelle Anochie. Enhanced Enantioselectivity of Native Α‐Cyclodextrins by the Synergy of Chiral Ionic Liquids in Capillary Electrophoresis. Journal of separation science, 41, no. 24 (2018): 4525-32.

5. Chunlai Feng#, Mengjie Rui#, Haijun Shen, Yuanrong Xin, Jie Zhang, Jun Li, Lixiang Yue, Wenlong Lai, Ximing Xu*.Tumor-specific delivery of doxorubicin through conjugation of pH-responsive peptide for overcoming drug resistance in cancer, International Journal of Pharmaceutics, 2017, 528 (1-2):322-333.

6. Mengjie Rui#, Yuanrong Xin , Ran Li, Yanru Ge, Chunlai Feng*, and Ximing Xu*. Targeted Biomimetic Nanoparticles for Synergistic Combination Chemotherapy of Paclitaxel and Doxorubicin, Molecular Pharmaceutics, 2017, 14 (1): 107-123.

7. Mengjie Rui#, Yang Qu, Tong Gao, Yanru Ge, Chunlai Feng*, and Ximing Xu*. Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells, International Journal of Nanomedicine, 2017, 12: 217-237.

8. Mengjie Rui#, Hailing Tang, Yan Li, Xiaohui Wei, and Yuhong Xu*. Recombinant High Density Lipoprotein Nanoparticles for Target-Specific Delivery of siRNA. Pharmaceutical research, 2013, 30 (5): 1203-14.

9. Mengjie Rui#, Wei Guo, Qian Ding, Xiaohui Wei, Jianrong Xu, and Yuhong Xu*. Recombinant high-density lipoprotein nanoparticles containing gadolinium-labeled cholesterol for morphologic and functional magnetic resonance imaging of the liver. International journal of nanomedicine, 2012, 7: 3751-3768.

10. Hailing Tang, Xiaojing Chen, Mengjie Rui, Wenqiang Sun, Jian Chen, Jinliang Peng, and Yuhong Xu*. Effects of surface displayed targeting ligand GE11 on liposome distribution and extravasation in tumor. Molecular Pharmaceutics, 2014, 11 (10): 3242–3250.

11. Yan Li, Mengjie Rui, Hailing Tang, and Yuhong Xu*. The distribution and cell uptake of ApoA1 modified lipid carriers of siRNA in mouse liver in vivo. Asian Journal of Pharmaceutical Sciences, 2013, 8: 228-233.

12. Junhua Mai, Shuxian Song, Mengjie Rui, Dan Liu, Qian Ding, Jinliang Peng, Yuhong Xu*. A synthetic peptide mediated active targeting of cisplatin liposomes to Tie2 expressing cells. Journal of Controlled Release, 2009, 139 (3): 174–181. 2009.

13. Xiaomeng Zhang*, Huanjun Yang*, Ke Gu, Jian Chen, Mengjie Rui, and Guo-Liang Jiang. In vitro and in vivo study of a nanoliposomal cisplatin as a radiosensitizer. International journal of nanomedicine, 2011, 6: 437-444.

聯系方式:

辦公室:世界杯正规买球app2213

E-mail: mjrui@ujs.edu.cn

 

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