曹霞，女，博士，副教授，碩士生導師。主要從事納米藥物/基因傳遞及組織研究工作。先後主持多項國家及省級科研項目，并參與國家重大專項等多個項目的研究開發工作。發表SCI文章40餘篇（最高影響因子16.863）；獲美國授權發明專利3 項，中國授權發明專利18項；獲教育部技術發明二等獎1 項，科學技術進步獎一等獎1項。

聯系方式 世界杯正规买球app2315室，郵箱：caoxia@ujs.edu.cn

1）主要研究方向

基于微流控芯片技術的納米顆粒可控合成；

納米藥物遞送系統；

非病毒基因傳遞系統；

3D生物打印及組織工程構建；

2）教育及工作經曆

2001.09-2005.06，江蘇大學，藥學院，藥學，學士

2005.09-2008.06，江蘇大學，藥學院，藥劑，碩士

2008.09-2011.12，江蘇大學，醫學院，臨床檢驗診斷學，博士

2012.04至今，江蘇大學，藥學院，藥劑教研室，副教授

3）留學經曆

2016.6-2019.8 美國哈佛醫學院，博士後

4）主持的科研項目

國家自然基金委，青年科學基金項目，81503025，熒光碳點介導的納米基因傳遞及其誘導腦膠質瘤幹細胞分化。

中國博士後面上項目，2014M560410、混雜納米基因載體構建及幹細胞傳遞研究

江蘇省博士後科研資助，1401023B，混雜納米基因載體構建及幹細胞傳遞研究

5）授權國際專利

[1] A Formulation of Silymarin with High Efficacy and Prolonged Action and the Preparation Method Thereof

[2] Ximing Xu, Jiangnan Yu, Xia Cao, Yuan Zhu. A Formulation of Silybinin with High Efficacy and Prolonged Action and the Preparation Method Thereof, US9023388, Date of Patent: May 5, 2015.

[3] Ximing Xu, Jiangnan Yu, Yuan Zhu, Xia Cao. A Highly Efficient and Long-acting Slow-release formulation of Poorly Soluble Drugs and Preparation Method Thereof, US 9,283,190, Date of Patent:03/15/2016.

6) 授權國内專利

[1] 以脂筏修飾的色譜柱及其制法和在中藥抗腫瘤活性部位篩選中的應用

[2] 一種合歡皮抗腫瘤有效組分提取物及其制法和用途

[3] 炒北葶苈子抗腫瘤有效組分提取物及其制法和用途

[4] 北葶苈子抗腫瘤有效組分提取物及其制法和用途

[5] 金針菇抗腫瘤有效組分提取物及其制法和用途

[6] 金針菇中具有抗腫瘤作用的可皂化提取物及其制法和用途

[7] 鈣離子化介孔二氧化矽納米粒基因傳遞系統及其制法

[8] 一種載有基因的磷酸鈣複合納米粒及其制法與用途

[9] 陽離子化杏鮑菇多糖納米粒基因傳遞系統及其制法

[10] 陽離子化當歸多糖納米粒基因傳遞系統及其制法

[11] 一種基因傳遞系統的三維納米支架及其制備與應用

[12] 陽離子化的桑葉多糖納米粒基因載體及其制法，

[13] 離子化多糖納米粒基因傳遞系統及其制法

[14] 陽離子化枸杞多糖納米粒基因傳遞系統及其制法

[15] 一種水飛薊素高效長效制劑及其制法

[16] 難溶性藥物高效長效緩釋制劑及其制法

[17] 餘江南，曹霞，徐希明，朱源. 一種水飛薊賓高效長效制劑及其制法

[18] 2-氨基-4-羰基-7-（3,4-二甲氧苯甲基）-5-乙烯基-6,7-二氫-3H-吡咯并[2，3-d]嘧啶的制法

7）近5年發表文章

[1] J. Gong, C.C.L. Schuurmans, A.M.V. Genderen, X. Cao, W. Li, F. Cheng, J.J. He, A. Lopez, V. Huerta, J. Manriquez, R. Li, H. Li, C. Delavaux, S. Sebastian, P.E. Capendale, H. Wang, J. Xie, M. Yu, R. Masereeuw, T. Vermonden, Y.S. Zhang, Complexation-induced resolution enhancement of 3D-printed hydrogel constructs, Nat Commun, 2020, 11(1): 1267.

[2] X. Cao, R. Ashfaq, F. Cheng, S. Maharjan, J. Li, G. Ying, S. Hassan, H. Xiao, K. Yue, Y.S. Zhang, Bioprinting: A Tumor-on-a-Chip System with Bioprinted Blood and Lymphatic Vessel Pair (Adv. Funct. Mater. 31/2019), Advanced Functional Materials, 2019, 29(31): 1970217.

[3] Q. Wang, M. Guo, M. Adu-Frimpong, K. Zhang, Q. Yang, E. Toreniyazov, H. Ji, X. Xu, X. Cao, J. Yu; Self-Micro-Emulsifying Controlled Release of Eugenol Pellets: Preparation, In vitro/In vivo Investigation in Beagle Dogs, AAPS PharmSciTech, 2019, 20(7): 284.

[4] A. Polat, S. Hassan, I. Yildirim, L. E. Oliver, M. Mostafaei, S. Kumar, S. Maharjan, L. Bourguet, X. Cao, G. Ying, M. Eyvazi Hesar, Y. S. Zhang; A miniaturized optical tomography platform for volumetric imaging of engineered living systems, Lab Chip, 2019, 19(4): 550-561.

[5] W. Deng, F. Shao, Q. He, Q. Wang, W. Shi, Q. Yu, X. Cao, C. Feng, S. Bi, J. Chen, P. Ma, Y. Li, A. Gong, S. Tong, J. Yu, M. Spector, X. Xu, Z. Zhang; EMSCs Build an All-in-One Niche via Cell-Cell Lipid Raft Assembly for Promoted Neuronal but Suppressed Astroglial Differentiation of Neural Stem Cells, Adv Mater, 2019, 31(10): e1806861.

[6] F. Cheng, X. Cao, H. Li, T. Liu, X. Xie, D. Huang, S. Maharjan, H. P. Bei, A. Gomez, J. Li, H. Zhan, H. Shen, S. Liu, J. He, Y. S. Zhang; Generation of Cost-Effective Paper-Based Tissue Models through Matrix-Assisted Sacrificial 3D Printing, Nano Lett, 2019, 19(6): 3603-3611.

[7] G. L. Ying, N. Jiang, S. Maharjan, Y. X. Yin, R. R. Chai, X. Cao, J. Z. Yang, A. K. Miri, S. Hassan, Y. S. Zhang; Aqueous Two-Phase Emulsion Bioink-Enabled 3D Bioprinting of Porous Hydrogels, Adv Mater, 2018, 30(50): e1805460.

[8] Q. Wang, Q. Yang, X. Cao, Q. Wei, C. K. Firempong, M. Guo, F. Shi, X. Xu, W. Deng, J. Yu; Enhanced oral bioavailability and anti-gout activity of [6]-shogaol-loaded solid lipid nanoparticles, Int J Pharm, 2018, 550(1-2): 24-34.

[9] Q. Wang, Q. Wei, Q. Yang, X. Cao, Q. Li, F. Shi, S. S. Tong, C. Feng, Q. Yu, J. Yu, X. Xu; A novel formulation of [6]-gingerol: Proliposomes with enhanced oral bioavailability and antitumor effect, Int J Pharm, 2018, 535(1-2): 308-315.

[10] J. Li, Q. Yu, H. Huang, W. Deng, X. Cao, M. Adu-Frimpong, J. Yu, X. Xu; Human chorionic plate-derived mesenchymal stem cells transplantation restores ovarian function in a chemotherapy-induced mouse model of premature ovarian failure, Stem Cell Res Ther, 2018, 9(1): 81.

[11] Q. Yu, J. Chen, W. Deng, X. Cao, Y. Wang, J. Zhou, W. Xu, P. Du, Q. Wang, J. Yu, X. Xu; Direct reprogramming of mouse fibroblasts into neural cells via Porphyra yezoensis polysaccharide based high efficient gene co-delivery, J Nanobiotechnology, 2017, 15(1): 82.

[12] Q. Yu, J. Chen, W. Deng, X. Cao, M. Adu-Frimpong, J. Yu, X. Xu; Neural differentiation of fibroblasts induced by intracellular co-delivery of Ascl1, Brn2 and FoxA1 via a non-viral vector of cationic polysaccharide, Biomed Mater, 2017, 13(1): 015022.

[13] J. Chen, Q. Wang, J. Zhou, W. Deng, Q. Yu, X. Cao, J. Wang, F. Shao, Y. Li, P. Ma, M. Spector, J. Yu, X. Xu; Porphyra polysaccharide-derived carbon dots for non-viral co-delivery of different gene combinations and neuronal differentiation of ectodermal mesenchymal stem cells, Nanoscale, 2017, 9(30): 10820-10831.

[14] J. Zhou, W. Deng, Y. Wang, X. Cao, J. Chen, Q. Wang, W. Xu, P. Du, Q. Yu, J. Chen, M. Spector, J. Yu, X. Xu; Cationic carbon quantum dots derived from alginate for gene delivery: One-step synthesis and cellular uptake, Acta Biomater, 2016, 42209-219.

[15] H. Y. Zhang, W. Q. Xu, Y. Y. Zheng, E. Omari-Siaw, Y. Zhu, X. Cao, S. S. Tong, J. N. Yu, X. M. Xu; Octreotide-periplocymarin conjugate prodrug for improving targetability and anti-tumor efficiency: synthesis, in vitro and in vivo evaluation, Oncotarget, 2016, 7(52): 86326-86338.

[16] H. Y. Zhang, W. Q. Xu, Y. W. Wang, E. Omari-Siaw, Y. Wang, Y. Y. Zheng, X. Cao, S. S. Tong, J. N. Yu, X. M. Xu; Tumor targeted delivery of octreotide-periplogenin conjugate: Synthesis, in vitro and in vivo evaluation, Int J Pharm, 2016, 502(1-2): 98-106.

[17] H. Y. Zhang, C. K. Firempong, Y. W. Wang, W. Q. Xu, M. M. Wang, X. Cao, Y. Zhu, S. S. Tong, J. N. Yu, X. M. Xu; Ergosterol-loaded poly(lactide-co-glycolide) nanoparticles with enhanced in vitro antitumor activity and oral bioavailability, Acta Pharmacol Sin, 2016, 37(6): 834-844.

[18] E. Omari-Siaw, Y. Zhu, H. Wang, W. Peng, C. K. Firempong, Y. W. Wang, X. Cao, W. Deng, J. Yu, X. Xu; Hypolipidemic potential of perillaldehyde-loaded self-nanoemulsifying delivery system in high-fat diet induced hyperlipidemic mice: Formulation, in vitro and in vivo evaluation, Eur J Pharm Sci, 2016, 85112-122.

[19] E. Omari-Siaw, Q. Wang, C. Sun, Z. Gu, Y. Zhu, X. Cao, C. K. Firempong, R. Agyare, X. Xu, J. Yu; Tissue distribution and enhanced in vivo anti-hyperlipidemic-antioxidant effects of perillaldehyde-loaded liposomal nanoformulation against Poloxamer 407-induced hyperlipidemia, Int J Pharm, 2016, 513(1-2): 68-77.

[20] C. K. Firempong, H. Y. Zhang, Y. Wang, J. Chen, X. Cao, W. Deng, J. Zhou, Q. Wang, S. S. Tong, J. Yu, X. Xu; Segetoside I, a plant-derived bisdesmosidic saponin, induces apoptosis in human hepatoma cells in vitro and inhibits tumor growth in vivo, Pharmacol Res, 2016, 110101-110.

[21] W. Deng, X. Cao, Y. Wang, Q. Yu, Z. Zhang, R. Qu, J. Chen, G. Shao, X. Gao, X. Xu, J. Yu; Pleurotus eryngii Polysaccharide Promotes Pluripotent Reprogramming via Facilitating Epigenetic Modification, J Agric Food Chem, 2016, 64(6): 1264-1273.

[22] W. Deng, X. Cao, Q. Wang, Y. Wang, J. Chen, Q. Yu, Z. Zhang, J. Zhou, W. Xu, P. Du, J. Chen, X. Gao, J. Yu, X. Xu; Prolonged Three-Dimensional Co-Delivery of Yamanaka Factors for Cell Reprogramming, ACS Appl Mater Interfaces, 2016, 8(31): 19916-19927.