性别: 男

職稱: 教授 （藥物化學）

通信地址: 世界杯正规买球app，江蘇鎮江市學府路301号，212013

Email: zhou_aihua@yahoo.com;ahz@ujs.edu.cn

手機：18796002400

Research  Group

學習和工作簡曆:

2010－至今      世界杯正规买球app

2008-2010.8     美國University of Wisconsin, Madison, Research Associate.

（從事抗癌藥物的合成，篩選，酶催化的天然産物的糖苷化反應，糖化學等研究）

2006-2008.9      美國University of Kansas CMLD藥物發現中心, 博士後（從事藥用化合物的設計，合成及高通量篩選)

2005                    美國密西西比州立大學化學系, 博士後(從事有機合成方法學和碳纖維等材料方面的研究)

1999.8-2004.12  美國Mississippi State University，獲有機化學，博士

(同時還修完該校化學工程博士畢業所需的所有化工理論課，工程數學課).

1995-1999.8     中國石化儀征化纖公司化工廠對苯二甲酸裝置工作。

1991.3-1995.8   中國石油遼陽化纖公司化工一廠和芳烴廠工作。

1991.3-1995.8   大連理工大學化工學院化學系，應用化學，碩士學位

1984-1988       大連理工大學化工學院化學工程系，化學工程，工學學士學位.

曾在多套石化裝置一線工作多年，對連續催化重整再生(UOP工藝)，芳烴抽提，歧化及異構化, 二甲苯分離 (旋轉吸附分子篩分離)，裂解汽油加氫，丙烷／丁烷制氫， PTA精對苯二甲酸裝置（BP-AMOCO工藝)有非常豐富的開車，停車，正常操作及事故處理經驗。除工藝外, 對多種催化劑，對各種自動化儀表，自動化操作及連鎖控制等也有相當的了解。

研究領域

1)      藥物發現, 抗癌活性天然産物的修飾, 糖化學，酶催化。

2)      有機合成方法學研究, 活性化合物合成，不對稱合成，過渡金屬催化。

3)      天然化合物的合成、修飾和篩選，磷化合物的合成。

4)      組合化學，多樣化合成，固/液相合成, 固/液相化試劑合成

5)      新藥、仿制藥的合成工藝開發，放大和質量标準的制定，藥物申報材料的撰寫,精細有機化工。

主要代表論文

在江蘇大學發表的文章

(1) Generation of thioethers via direct C-H functionalization with sodium benzenesulfinate as a

sulfur source, Org. Biomol. Chem., 2016, (Advance Article, DOI: 10.1039/C5OB02073E).

Yingcai Ding, Wei Wu, Wannian Zhao, Yiwen Li, Ping Xie, Youqin Huang, Yu Liu and Aihua Zhou*

( 2) Regioselective Coupling Reactions of Coumarins with Aldehydes or Di-tert-butyl Peroxide (DTBP) through a C(sp²)-H Functionalization Process, Eur. J. Org. Chem., 2016, (online, DOI:10.1002/ejoc.201501251).

Wannian Zhao, Lei Xu, Yingcai Ding, Ben Niu, Ping Xie, Zhaogang Bian, Denghong Zhang and Aihua Zhou*

(3) Regioselective C-S Bond Formation between Flavones and Arylsulfonyl Chloride through the Use of Ammonium Iodide, ChemCatChem, 2015, 7, 3464-3467.

Wannian Zhao, Aihua Zhou*

(4) Ammonium Iodide Induced Nonradical Regioselective Sulfenylation of Flavones via a C-H Functionalization Process, J. Org. Chem., 2015, 80, 9167-9175.

Wannian Zhao, Ping Xie, Zhaogang Bian, Aihua Zhou,* Haibo Ge,* Min Zhang, Yingcai Ding, and Lian Zheng

(5) Synthesis of Nitromethyl-Substituted Oxindole Derivatives via a Desulfonylation Cascade Synlett., 2015, 26, 635-638.

Ben Niu, Ping Xie, Zhaogang Bian, Wannian Zhao, Min Zhang, Yang Zhou, Lei Feng, Charles U. Pittman, Jr., and Aihua Zhou*

(6) A Summary of seven- and eight-membered ring sultam syntheses via three Michael addition reactions, Molecular Diversity, 2015, 19, 447-458.

Ben Niu, Ping Xie, Min Wang, Yanjie Wang, Wannian Zhao, Charles U. Pittman Jr., Aihua Zhou*

(7) Cascade Couplings of N-Alkyl-N-methacryloyl Benzamides with Ethers and Benzenesulfonohydrazides to Generate Isoquinoline-1,3(2H,4H)-dione Derivatives , J. Org. Chem. 2015, 80, 4176-4183.

Min Zhang, Ping Xie, Wannian Zhao, Ben Niu, Wei Wu, Zhaogang Bian, Charles Pittman, Jr. Aihua Zhou*

(8) Regioselective Cross-Couplings of Coumarins and Flavones with Ethers via C(sp³)-H Functionalization, J. Org. Chem. 2015, 80, 7251-7257.

Ben Niu, Wannian Zhao, Yingcai Ding, Zhaogang Bian, Charles U. Pittman Jr., Aihua Zhou* and Haibo Ge

(9) Generation of ArS-substituted Flavone Derivatives Using Aryl Thiols as Sulfenylating Agents, RSC Advances, 2015, 5, 59861-59864.

Wannian Zhao, Ping Xie, Zhaogang Bian, Haibo Ge, Ben Niu, Yingcai Ding, Aihua Zhou*

(10) Metal-free Syntheses of Oxindole Derivatives via a Benzoylation/Substitution /Desulfonylation/Cyclization Cascade, RSC Adv., 2014, 4, 43525-43528

Ben Niu, Ping Xie, Wannian Zhao, Yang Zhou, Zhaogang Bian, Charles U. Pittman,Jr and Aihua Zhou*

(11) Synthesis of Isoquinoline-1,3(2H,4H)-dione Derivatives via Cascade Reactions of N-alkyl-N-methacryloyl Benzamide with Aryl Aldehydes, Org. Biomol. Chem., 2014, 12, 7690-7693.

Wannian Zhao, Ping Xie, Min Zhang, Ben Niu, Zhaogang Bian, Charles Pittman Jr. and Aihua Zhou*

(12) Diversity-Oriented Syntheses: Coupling Reactions Between Electron-Deficient Olefins and Aryl Aldehydes via C(sp²)-H Functionalization, ACS Comb. Sci. 2014, 16, 454-458.

Ben Niu, Lei Xu, Ping Xie, Min Wang, Wannian Zhao, Charles U. Pittman, Jr., and Aihua Zhou*

(13) Copper-catalyzed Oxidative Cascade Coupling of N-alkyl-N-phenylacrylamides with Aryl Aldehydes RSC Adv., 2014, 4, 6854-6857.

Weiwei Gong, Lei Xu, Tao Ji, Ping Xie, Xueyong Qi, Charles U. Pittman, Jr.and Aihua Zhou*

(14) Syntheses of Five- and Seven-membered Ring Sultam Derivatives via Michael Addition and Baylis-Hillman Reactions, Tetrahedron, 2013, 69, 2369-2375.

Kun Tong, Jinchang Tu, Xueyong Qi, Min Wang, Yanjie Wang, Haizhen Fu,Charles U. Pittman, Jr., and Aihua Zhou*

(15) Parallel Syntheses of Eight-Membered Ring Sultams via Two Cascade Reactions in Water, ACS Comb. Sci. 2013, 15, 595-600.

Tao Ji, Yanjie Wang, Min Wang, Ben Niu, Ping Xie, Charles U. Pittman, Jr., and Aihua Zhou*

(16) Selective Synthesis of Seven- and Eight-Membered Ring Sultams via Two Tandem Reaction Protocols from One Starting Material .Org. Lett., 2012, 14 (14), 3700-3703.

Min Wang, Yanjie Wang, Xueyong Qi, Guohua Xia, Kun Tong, Jinchang Tu, Charles,U. Pittman, Jr., and Aihua Zhou*

在美國期間發表的文章:

(17) Automated Synthesis of a 184-Member Library of Thiadiazepan-1,1-dioxide-4-ones

Erik Fenster, Toby R. Long, Qin Zang, David Hill, Benjamin Neuenswander, Gerald H.

ACS Comb. Sci. 2011, 13, 244-250.

Lushington, Aihua Zhou, Conrad Santini, and Paul R. Hanson,

(18) Reactions of 2-Methyl- and 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine with Aroyl Chlorides: Diverse Reactivities of Cyclic Ketene N,N-Acetals Generated in situ

Synthesis 2010, 7, 1209-1216.

Guozhong Ye, Sabonie Chatterjee, Aihua Zhou, Bobby Lloyd Barker, et al, Charles U.Pittman,

(19) Tandem Reactions of 2-Methylimidazoline and 1,2-Dimethylimidazoline with Various Benzoyl Chlorides Synthesis 2010, 1, 141-152.

Guozhong Ye, Chunlong Chen，Sabornie Chatterjee, Collier, Willard E., Zhou Aihua, Yingquan Song, Debbie J. Beard, Charles U. Pittman,

(20) Push–pull alkenes from cyclic ketene-N,N’-acetals: a wide span of double bond lengths and twist angles Tetrahedron 2010, 66, 2919-2927.

Guozhong Ye, Sabornie Chatterjee, Min Li, Aihua Zhou, Yingquan Song, Bobby Lloyd Barker, Chunlong Chen, Debbie J. Beard, William P. Henry, Charles U. Pittman,

(21) “Click, Click, Cyclize”: A DOS Approach to Sultams Utilizing Vinyl Sulfonamide Linchipins

Org. Lett. 2009, 11, 531-534.

Aihua Zhou, Paul R. Hanson,

(22) Push-pull Alkenes by Reacting N,N-dimethyl Cyclic Ketene N,N-Acetals With Isocyanates: Synthesis, Structures and Reactivities Tetrahedron Lett. 2009, 50, 2135-2139.

Guozhong Ye, William P. Henry, Chunlong Chen, Aihua Zhou, Charles U. Pittman,

(23) a-Haloarylsulfonamides: Multiple Cyclization Pathways to Skeleally Diverse Benzofused Sultams Tetrahedron, 應邀文章, 2009, 65, 3180-3188.

Dinesh Kumar Rayabarapu, Aihua Zhou, Kyu Ok jeon, Thiwanka Samarakoon, Alan Rolfe, Hina Siddiqui and Paul R. Hanson,

(24) Synthesis of Sultam Scaffolds via Intramolecular Oxa-Michael and Diastereoselective Baylis-Hillman Reaction Org. Lett. 2008, 10, 2951-2954.

Aihua Zhou, Paul R. Hanson

(25) 1,8-NaphthyridinetetraonesfromOne-pot Reactions of 2-Methyllimidazoline or 2-Methyl-1,4,5,6-Tetrahydropyrimidinewith1,3-DiacidChlorides J. Org. Chem. 2008, 73, 5170-5172.

Guozhong Ye, Aihua Zhou, William P. Henry, Yingquan Song, Sabornie Chatterjee, Debbie J. Beard, Charles U. Pittman

(26) Stereoselective Radical Cyclizations of N-(2-Halobenzoyl)-Cyclic Ketene-N,X (X=O, S)-Acetals”Tetrahedron 2006, 62, 4093-4102.

Aihua Zhou, Moses N. Njogu, Charles U. Pittman

(27) “Push-Pull” and Spirobicyclic Structures by Reacting N-Methyl Cyclic Ketene-N,X (X =S, O)-acetals with Isocyanates and Isothiocyanates Tetrahedron 2006, 62, 4188-4200.

Aihua Zhou, Charles U. Pittman

(28) Generation of Cyclic Ketene-N,X-Acetals (X=O,S) from 2-Alkyl-1,3-oxazolines and 2-Alkyl-1,3-thiazolines. Reactions with Acid Chlorides, 1,3-Diacid Chlorides and N-(Chlorocarbonyl) Isocyanate Synthesis 2006, 1, 37-48.

Aihua Zhou, Charles U. Pittman

(29) Reactions of Cyclic Ketene-N,S-acetals with Isocyanates, Isothiocyanate and Vinylisocyanates Synlett. 2006, 2, 201-206.

Aihua Zhou, Liwei Cao, Haiqing Li, Zhuqing Liu, Charles U. Pittman

(30) Ring-opening Reactions of Cyclic Ketene-N,X-acetals (X=O, S) with Carboxylic Acids, Phenols and Thiols J. Comb. Chem. 2006, 8, 262-267.

Aihua Zhou, Charles U. Pittman

(31) Cyclization Reactions of Oxazolines and Thiazolines with Diacid Chlorides”

Tetrahedron Lett. 2005, 46, 2045-2048.

Aihua Zhou, Charles U. Pittman,

(32) Synthesis of Library of 1,5,2-Dithiazepine-1,1-Dioxide. Part 1: A One-Pot ulfonylation/Thia-Michaelprotocol. Heterocycles. 2012, 86, 1661-1674.

Zang, Q.; Zhou, A.; Javed, S.; Maity, P. K.; Knudtson, C. A.; Bi. D.; Hastings, J. J.; Basha, F. Z.; Hanson, P. R.

(33) Aryl Radical Cyclization of N-2-Halobenzoyl Cyclic Ketene-N,S-acetals

Tetrahedron Lett. 2005, 46, 3801-3805.

Aihua Zhou, Charles U. Pittman

(34) Reactions of 2-Methylthiazolines and N-Methyl Cyclic Ketene-N,S-acetals with Acid Chlorides

Tetrahedron Lett. 2004, 45, 8899-8903

Aihua Zhou, Charles U. Pittman

(35) Multi Capillary Flow Reactor: Synthesis of 1,2,5-thiadiazepane 1,1-dioxide Library Utilizing One-Pot Elimination and Inter-/Intramolecular Double aza-Michael Addition Via Microwave- Assisted, Continuous Flow Organic Synthesis (MACOS). J. Flow Chem. 2012, 2, 118-123.

Ullah, F.; Zang, Q.; Javed, S.; Zhou, A.; Knudtson, C. A.; Bi. D.; Hanson, P. R.; Organ, M. G.

(36) Application of a Double Aza-Michael Reaction in a ‘Click, Click, Cy-Click’

Strategy: From Bench to Flow, Synthesis 2011, 17, 2743–2750.

Qin Zang, Salim Javed, Farman Ullah, Aihua Zhou, Christopher A. Knudtson, Danse Bi, Fatima Z. Basha, Michael G. Organ, Paul R. Hanson

(37) Synthesis of Library of 1,5,2-Dithiazepine 1,1-Dioxide. Part 2: Routes to bicyclic Sultams.

Heterocycles. 2012, 86, 1675-1688.

Zang, Q.; Javed, S.; Zhou, A.; Maity, P. K.; Knudtson, C. A.; Bi. D.; Hastings, J. J.; Basha, F. Z.; Hanson, P. R

教授過的課程：

（1）藥物化學

（2）藥物設計和研發過程

（3）化學藥物工程和技術

（4）化工原理

（5）光譜

（6）現代藥物合成

（7）藥學概論

其他:

1.  美國化工學會會員 (Member of American Chemical Society).

2. RSC Advances，Tetrahedron, Tetrahedron Lett. Org. Biomol. Chem.等期刊審稿人.